February New Deal Reads

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In New Deal Reads we have prepared for you a selection of relevant papers in the field of IBD and nanotechnology so you can stay tuned with the new advances:

1. Local delivery of macromolecules to treat diseases associated with the colon, Bak A, .Ashford M, Brayden D.J. Journal: Advanced Drug Delivery Reviews in December 2018

The local delivery of treatments to the colon remains a clinical challenge. The permeability of the intestine poses a hurdle to get to the affected area. This situation is further complicated when the treatment is based on big-sized drugs like macromolecules. To tackle this issue, this publication reviews the latest breakthroughs in the field.

It covers some advances regarding drug delivery techniques, including also potential formulation strategies that could improve the macromolecules delivery. Besides, it opens the door for new potential research lines to face the challenges of drug delivery. Read more

2.Oral Delivery of Macromolecular Drugs, Savla R, Hartwig O, Lim Chin WW, Loretz B & Lehr C-M  Pharm. Technol. Eur. 30: 22–26

Macromolecules are new treatments with great potential to treat IBD. These drugs are typically administered by injections, but scientists are trying to find an oral formulation to improve the patients’ comfort and wellbeing.

Read this article for fuller information on the latest approaches for the delivery of macromolecular drugs, the current pre- and post- absorption challenges, as well as the advances and obstacles. Furthermore, they review available models and experiments with a particular focus on the IBD conditions context. Read more

3. Overcoming immunogenicity issues of HIV p24 antigen by the use of innovative nanostructured lipid carriers as delivery systems: evidences in mice and non-human primates Bayon E Morlieras J Dereuddre-Bosquet N Gonon A Gosse L et. al. NPJ vaccines 2018 vol: 3 pp: 46

For years, scientists have tried to eradicate HIV but the virus is still uncontrolled. Unfortunately, the few prophylactic vaccines that have reached clinical trial, have failed to effectively fight the virus highlighting the urgency of developing smart and innovative solutions.

Read this article to discover how scientists have found a way to deliver a macromolecule, HIV p24 antigen, using nanostructured lipid carriers (NLC). The small size of NCL, together with their stability and their safety, are features that make them very attractive for drug delivery and potential treatments to fight HIV. Read more



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