X. Sun, S. Dong, X. Li, et al. Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy. 2019. Nanomedicine: Nanotechnology, Biology, and Medicine

siRNA technology is a promising therapy for autoimmune diseases like inflammatory bowel disease (IBD) or rheumatoid arthritis, as it can silence the expression of genes responsible for the inflammation. However, the delivery of siRNA molecules to intestinal cells is still a challenge to overcome: siRNA’s chemical nature impairs these molecules to enter the cells and they are sensitive to enzymes that can destroy them.

Now researchers have developed pH-sensitive polymeric nanoparticles to protect siRNA molecules and to carry them to the inflamed joints in rheumatoid arthritis. This vehicle has shown to access the cells in in vitro models, but also a therapeutic effect in rat models for this disease. This progress may open the door to improve the delivery of siRNAs to the intestine in IBD. To the publication >