siRNA Targeting and Treatment of Gastrointestinal Diseases. Chevalier R. 2019, Clinical and Translational Science

siRNA is considered as an effective way to treat some gastrointestinal diseases such as inflammatory bowel disease. This therapy can target with accuracy genes that contribute to the excessive inflammation found in this illness. Nevertheless, the delivery of siRNA to the cells of interest remains a challenge as the harsh environment of the gut harms these molecules before they reach their target.

The new delivery systems have as a goal helping the drug to reach the intestine easier and to protect siRNA molecules during their journey. This review discusses several different delivery strategies that pursue a successful and accurate siRNA administration.
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