Functional lipid polymeric nanoparticles for oral drug delivery: Rapid mucus penetration and improved cell entry and cellular transport. Liu et al. 2019. Nanomedicine: Nanotechnology, Biology, and Medicine.
Many IBD drugs are administered orally and thus, they have to travel through the gastrointestinal tract to reach the intestine. During this transit, the drug must overcome some biological barriers in order to reach its target area, mainly the mucus and the epithelial cell layers. Nanoparticles stand as one of the most promising drug delivery strategies, but the chemical composition of the pill coating may hinder the drug capacity to cross these biological barriers and also to reduce its cellular uptake.
In this article, researchers have developed a new formulation consisting of a detachable envelope integrated with lipid polymeric nanoparticles. This combination showed an increased cellular uptake when tested in vitro and an improved capacity to cross the biological barriers when administered to mice. Nanocarriers with a dissociable shell may improve the oral delivery of therapeutic compounds such as IBD treatments.