Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy. Jacob, E. M., Borah, A., Pillai, S. C., & Kumar, D. S. Nanomaterials (Basel, Switzerland), vol. 10,12 2460. 9 Dec. 2020.
To date, the causes for Inflammatory Bowel Disease (IBD) remain a mystery. However, recent studies show that the onset and progress of the disease may involve an interaction between genetic and environmental factors, the immune system and the microbiota living in our gut. This complexity makes it difficult to find adequate treatment options for patients. Often, these therapies consist of high doses of immunosuppressants and anti-inflammatory medicines that, although improve IBD symptoms, may have side effects. To overcome these limitations, drugs based on nanoparticles, like the one developed at New Deal project, have risen as an alternative strategy.
In this article, the authors review the association of factors involved in the pathogenesis of IBD and the conventional therapies used for its treatment. They present the nanodrug delivery system as a good alternative, assessing advantages and current challenges where improvements could be made.