X. Sun, S. Dong, X. Li, et al. Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy. 2019. Nanomedicine: Nanotechnology, Biology, and Medicine siRNA technology is a promising therapy for autoimmune diseases like inflammatory bowel disease (IBD) or rheumatoid arthritis, as it can silence the expression of genes responsible for the inflammation. However, the delivery of … Read More
Silencing IBD: when a tiny molecule can make a great difference.
Take a quick look on your body. We are a combination of one hundred thousand billion cells. Inside each one of them, we can find all our DNA that holds more than twenty thousand genes. DNA remains in the cell nucleus and, when its information is needed, it doesn’t leave it. Instead, it is transcribed in a different kind of … Read More
World IBD Day 2019
Over ten million people worldwide live with IBD, a disease that goes unnoticed by most of the people around them. To increase its visibility today we celebrate world IBD day. Under the motto “Making the invisible visible” over 50 countries are joining this initiative to show support to all the IBD warriors out there and to show to the society … Read More
May New Deal Reads
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function. De Vries L. C. S et al. Inflammatory Bowel Disease. 25 (4) 2019. Janus kinases (JAKs) are involved in the intestinal inflammation found in IBD. A common treatment for this disease is tofacitinib, a drug that inhibits different JAKs. Although this therapy is effective, it doesn’t target only … Read More
Living with IBD: treatments
If you have reached this post, maybe you have been recently diagnosed with inflammatory bowel disease or know someone who has been. They are very common: over two million people in Europe live with an IBD, being Crohn’s disease and Ulcerative colitis the most widely spread. The principal characteristic of IBD conditions is the swelling of the digestive tract, which … Read More
April New Deal Reads
1. Targeting JAK-STAT signal transduction in IBD. Soendergaard C. et al. Pharmacology & Therapeutics 192(2018): 100-111 Antibody-based biological drugs were a significant advance for IBD treatments, but unfortunately a high percent of patients doesn’t respond well to this therapy highlighting the need for alternative therapies. Recent studies have shown the great potential of JAK inhibitors to face this unmet medical … Read More
Keep Calm and research on! Consortium meeting in London
Six months passed by since our last meeting in Barcelona so it was time for another face to face meeting for the members of the New Deal consortium. This time in London and hosted by our partners from BOYDS we celebrated our third Annual Meeting to discuss about our progress and define the future steps of our project. Moreover we … Read More
February New Deal Reads
In New Deal Reads we have prepared for you a selection of relevant papers in the field of IBD and nanotechnology so you can stay tuned with the new advances: 1. Local delivery of macromolecules to treat diseases associated with the colon, Bak A, .Ashford M, Brayden D.J. Journal: Advanced Drug Delivery Reviews in December 2018 The local delivery of … Read More
NEW DEAL was rewarded at Mayoly’s Forum
The Mayoly Management Forum took place from the 5th to the 8th of February, in Valence. The event gathered all the managers from Mayoly and at this occasion the New Deal project was presented. A new nanotherapy research for inflammatory bowel diseases The goal of the project NEW DEAL is to design and validate a new targeted therapy against inflammatory bowel diseases (IBDs). This … Read More
New EU project develops a highly selective and local therapy for Inflammatory Bowel Diseases
The innovations introduced by NEW DEAL strengthen the leadership of Europe in the field of advanced therapies and in particular, in nanotherapies. An alternative therapy for inflamatory bowel diseases (IBDs) The goal of the new European project NEW DEAL is to design and validate a new targeted therapy against inflammatory bowel diseases (IBDs). This therapy is aimed at treating patients … Read More
